# Release of Nextclade 2.0.0: Thread for info, comments, questions

**URL:** <https://nextstrain.discourse.group/t/release-of-nextclade-2-0-0-thread-for-info-comments-questions/1145>\
**Category:** General\
**Created:** [June 16, 2022, 6:26pm UTC](https://nextstrain.discourse.group/t/release-of-nextclade-2-0-0-thread-for-info-comments-questions/1145 "2022-06-16T18:26:12Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![corneliusroemer](https://yyz1.discourse-cdn.com/flex031/user_avatar/nextstrain.discourse.group/corneliusroemer/32/175_2.png) [@corneliusroemer](https://nextstrain.discourse.group/u/corneliusroemer)\
**Post date:** [June 16, 2022, 6:26pm UTC](https://nextstrain.discourse.group/t/release-of-nextclade-2-0-0-thread-for-info-comments-questions/1145/1 "2022-06-16T18:26:12Z")

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We’ve released Nextclade 2.0.0 web and will the CLI v2 in the next week or two.

I’m collecting links to Threads/Changelog etc. here. Also if you have any questions feel free to ask, I’ll try to get back as soon as possible.

Announcement thread: [https://twitter.com/nextstrain/status/1537481958284210177?s=20&t=zUXU6zqtjzDCXOue5DdtLQ](https://twitter.com/nextstrain/status/1537481958284210177?s=20&t=zUXU6zqtjzDCXOue5DdtLQ)

Further info thread: [https://twitter.com/CorneliusRoemer/status/1537495606540877827?s=20&t=zUXU6zqtjzDCXOue5DdtLQ](https://twitter.com/CorneliusRoemer/status/1537495606540877827?s=20&t=zUXU6zqtjzDCXOue5DdtLQ)

Changelog: [nextclade/CHANGELOG.md at master · nextstrain/nextclade · GitHub](https://github.com/nextstrain/nextclade/blob/master/CHANGELOG.md)

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**Author:** ![corneliusroemer](https://yyz1.discourse-cdn.com/flex031/user_avatar/nextstrain.discourse.group/corneliusroemer/32/175_2.png) [@corneliusroemer](https://nextstrain.discourse.group/u/corneliusroemer)\
**Post date:** [June 16, 2022, 7:35pm UTC](https://nextstrain.discourse.group/t/release-of-nextclade-2-0-0-thread-for-info-comments-questions/1145/2 "2022-06-16T19:35:17Z")

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Here are two additional announcements (who knows, maybe they contain the snippet of info you’ve been looking for 😉 )

> We’ve released a rustified v2 of Nextclade (web only so far) together with 3 monkeypox datasets (all-clades, hMPXV-1, and 2022 outbreak lineage B.1)  
> You can already prepare CLI for v2 if you like (beta is available), we will release v2 CLI in 1-2 weeks - any testing, feedback etc. is much appreciated.  
> You don’t have to upgrade to v2 CLI if you don’t want to, old datasets will keep working, even new SC2 ones should for at least a month or more.  
> So no rush, but it could pay off and should be quite easy - CLI arguments change only slightly.  
> [https://github.com/nextstrain/nextclade/blob/master/CHANGELOG.md](https://github.com/nextstrain/nextclade/blob/master/CHANGELOG.md)  
> v2 is a lot faster (2-4x), can work with large genomes (like mpxv, v1 can’t!), aligns Omicron correctly (v1 struggled with Omicron 3’ end) and has a number of other convenience features.  
> Have a look at these two threads for some more details and check out the Changelog for a complete list.  
> [https://twitter.com/nextstrain/status/1537481958284210177?s=20&t=zUXU6zqtjzDCXOue5DdtLQ](https://twitter.com/nextstrain/status/1537481958284210177?s=20&t=zUXU6zqtjzDCXOue5DdtLQ)  
> [https://twitter.com/CorneliusRoemer/status/1537495606540877827?s=20&t=zUXU6zqtjzDCXOue5DdtLQ](https://twitter.com/CorneliusRoemer/status/1537495606540877827?s=20&t=zUXU6zqtjzDCXOue5DdtLQ)  
> If you have any questions, please comment here, I’ll try to answer all questions.  
> Big thanks to [@Ivan Aksamentov (UniBasel/Nextstrain)](https://microbial-bioinfo.slack.com/team/U0192BQHJVA) who did most of the work!

> Together with version 2 of Nextclade web, we have released 3 monkeypox Nextclade datasets to help with clade assignment (according to new proposed nomenclature) and sequence QC.  
> If you have recent sequences that are likely 2022 outbreak related, it is probably best to start with the narrowest dataset (B.1) which is the least overwhelming.  
> If sequences are assigned a clade of “Outgroup”, you can try a broader dataset (either hMPXV-1 or the all-clades MPXV).  
> You can play with the 3 datasets on [clades.nextstrain.org](http://clades.nextstrain.org/), they are in position 2-4. There is example data available so you don’t need to get any sequences from Genbank/GISAID to try it out immediately.  
> The gene annotation and positions are always based on the NCBI ref sequence recently curated, so the genes are called `OPG001` etc.)