# Nexststrain RSV FullGenome clades

**URL:** <https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513>\
**Category:** Help and Getting Started\
**Created:** [December 19, 2023, 12:11am UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513 "2023-12-19T00:11:07Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![Thomas](https://avatars.discourse-cdn.com/v4/letter/t/e36b37/32.png) [@Thomas](https://nextstrain.discourse.group/u/Thomas)\
**Post date:** [December 19, 2023, 12:11am UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513/1 "2023-12-19T00:11:07Z")

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Thank you for this great resource!

Does anyone know where the nomenclature of the RSV genotypes based on FG is coming from? For RSV-A some clade names start with A.D. I have looked at Ramaekers et al. (2020) but was not able to find that nomenclature. [rsv/config/clades\_genome\_a.tsv at master · nextstrain/rsv · GitHub](https://github.com/nextstrain/rsv/blob/master/config/clades_genome_a.tsv), does seem to have the same nomenclature as Ramaekers (e.g. A1-A23 for RSV-A).

Thank you in advance!  
Thomas

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**Author:** ![corneliusroemer](https://yyz1.discourse-cdn.com/flex031/user_avatar/nextstrain.discourse.group/corneliusroemer/32/175_2.png) [@corneliusroemer](https://nextstrain.discourse.group/u/corneliusroemer)\
**Post date:** [December 19, 2023, 3:37pm UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513/2 "2023-12-19T15:37:31Z")

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Welcome @Thomas and thanks for your great question!

Can you confirm that you were looking at this Nextstrain tree: [auspice](https://nextstrain.org/rsv/a/genome)?

The default clades include `A.D` and you’re right that this doesn’t match the clades.tsv that is linked from the description at the bottom of the build: [rsv/config/clades\_genome\_a.tsv at master · nextstrain/rsv · GitHub](https://github.com/nextstrain/rsv/blob/master/config/clades_genome_a.tsv)

 ![image](https://canada1.discourse-cdn.com/flex031/uploads/nextstrain/original/1X/6e955501dd01accbe2c718ffe66f0e9185c27aca.png)

The clade nomenclature shown is the new “consortium” clade system under active development. You can find the Github repo defining the clades here: [GitHub - rsv-lineages/lineage-designation-A: RSV-A lineage definitions and proposals](https://github.com/rsv-lineages/lineage-designation-A) It’s a 3rd clade system, that uses lineage identifiers inspired by Pango lineages. As the clade system is still in beta stage there’s not yet an extensive specification out there.

I will open an issue on the RSV-A Github repo that the description needs to be updated. Thanks for noticing this and bringing it to our attention!

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**Author:** ![corneliusroemer](https://yyz1.discourse-cdn.com/flex031/user_avatar/nextstrain.discourse.group/corneliusroemer/32/175_2.png) [@corneliusroemer](https://nextstrain.discourse.group/u/corneliusroemer)\
**Post date:** [December 19, 2023, 4:16pm UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513/3 "2023-12-19T16:16:06Z")

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Should be fixed soon: [fix: Update description to point to new clade nomenclature by corneliusroemer · Pull Request #48 · nextstrain/rsv · GitHub](https://github.com/nextstrain/rsv/pull/48)  
Thanks for reporting @Thomas!

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**Author:** ![Thomas](https://avatars.discourse-cdn.com/v4/letter/t/e36b37/32.png) [@Thomas](https://nextstrain.discourse.group/u/Thomas)\
**Post date:** [December 19, 2023, 11:47pm UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513/4 "2023-12-19T23:47:07Z")

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Hi Cornelius,

Yes, this is the tree I looked at. Thanks a lot for pointing me to the Github repo defining the clades!

Best,  
Thomas

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**Author:** ![AngieHinrichs](https://yyz1.discourse-cdn.com/flex031/user_avatar/nextstrain.discourse.group/angiehinrichs/32/78_2.png) [@AngieHinrichs](https://nextstrain.discourse.group/u/AngieHinrichs)\
**Post date:** [February 14, 2024, 10:38pm UTC](https://nextstrain.discourse.group/t/nexststrain-rsv-fullgenome-clades/1513/5 "2024-02-14T22:38:45Z")

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@Thomas A preprint describing the new consortium clade system is available here:

> **[The unified proposal for classification of human respiratory syncytial virus...](https://www.medrxiv.org/content/10.1101/2024.02.13.24302237v1)**
>
> A globally implemented unified classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. Here, we formulate the global consensus of HRSV classification based on the challenges and limitations of our...
